Corynebacterium bovis

Prevalence
Rare in Australia. It has been reported to be a common pathogen in athymic nude mouse colonies, JAALAS 2012 51(2):189-198.
 
Diagnosis
Bacterial culture of oral swabs and skin lesions with PCR as a confirmatory test.
 
Disease
Immunocompetent animals have transient infections.Immunodeficient animals may develop Coryneform hyperkeratosis with diffuse scaling of the skin which on histology is characterised by orthokeratotic hyperkeratosis and epidermal hyperplasia.
 
Strains
B6, BALB/c, DBA/2, C3H/HeN and Swiss mice develop low-level transient infections. SCID mice develop scaly lesions. Immunocompromised hairless/nude mice are fully susceptible.
 
Screening
Bacterial culture of enteric and oropharyngeal flushes / swabs.
 
Transmission
Direct contact with infected mice or humans. Aerosol. 
 
Significance
Increased toxicity of chemotherapeutic agents. Decreased growth of tumour transplants in nude mice.
 
Reading
  • Pathogenesis of C. bovis Strains in Immunodeficient Mice. VS Dole, Abstracts of Scientific Presentations, 2012 AALAS National Meeting, Minneapolis, Minnesota.
  • Corynebacterium bovis: Epizootiologic Features and Environmental Contamination in an Enzootically Infected Rodent Room. JAALAS 2012 51(2):189-198.
  • The Mouse in Biomedical research, Vol. 2: Diseases Fox and Barthold. Second Edn. Elsevier, Inc. 2007.
  • Pathology of Laboratory Rodents and Rabbits, 3rd Ed., Dean H Percy & Stephen W Barthold, 2007.
  • Infectious Diseases of Mice and Rats National Research Council 1991.