Corynebacterium bovis

Rare in Australia. It has been reported to be a common pathogen in athymic nude mouse colonies, JAALAS 2012 51(2):189-198.
Bacterial culture of oral swabs and skin lesions with PCR as a confirmatory test.
Immunocompetent animals have transient infections.Immunodeficient animals may develop Coryneform hyperkeratosis with diffuse scaling of the skin which on histology is characterised by orthokeratotic hyperkeratosis and epidermal hyperplasia.
B6, BALB/c, DBA/2, C3H/HeN and Swiss mice develop low-level transient infections. SCID mice develop scaly lesions. Immunocompromised hairless/nude mice are fully susceptible.
Bacterial culture of enteric and oropharyngeal flushes / swabs.
Direct contact with infected mice or humans. Aerosol. 
Increased toxicity of chemotherapeutic agents. Decreased growth of tumour transplants in nude mice.
  • Pathogenesis of C. bovis Strains in Immunodeficient Mice. VS Dole, Abstracts of Scientific Presentations, 2012 AALAS National Meeting, Minneapolis, Minnesota.
  • Corynebacterium bovis: Epizootiologic Features and Environmental Contamination in an Enzootically Infected Rodent Room. JAALAS 2012 51(2):189-198.
  • The Mouse in Biomedical research, Vol. 2: Diseases Fox and Barthold. Second Edn. Elsevier, Inc. 2007.
  • Pathology of Laboratory Rodents and Rabbits, 3rd Ed., Dean H Percy & Stephen W Barthold, 2007.
  • Infectious Diseases of Mice and Rats National Research Council 1991.