Corynebacterium kutscheri

Prevalence
Rare.
 
Diagnosis
Bacterial culture from gastrointestinal tract, oral cavity, and lesions such as abscesses. Histology with presence of abscesses with small gram-positive rods is indicative.  
 
Disease
It is usually asymptomatic.  Acute outbreaks of pyogenic infections with bacteraemia and lesions are abscesses in lungs, liver, kidneys, skin, synovium/arthritis.
 
Strains
Susceptible mouse strains: BALB/c nude, A/J, CBA/N, MPS, and BALB/cCr. Most resistant strains were C57Bl/6Cr, B10.BR/SgSn, ddY and ICR. 
 
Screening
Quarterly.
 
Transmission
Probably Faecal-oral.
 
Duration
Asymptomatic, acute or chronic infections. 
 
Durability
C.kutscheri is susceptible to most disinfectants used in animal facilities.
 
Significance
Pyogenic infections will result in significant disease and losses. 
 
Control
Pathogen exclusion by rederivation through caesarean section or embryo transfer onto/into pathogen free dams is recommended.
 
Reading
  • The Mouse in Biomedical research, Vol. 2: Diseases Fox and Barthold. Second Edn. Elsevier, Inc. 2007.
  • Pathology of Laboratory Rodents and Rabbits, 3rd Edn., Dean H Percy & Stephen W Barthold, 2007.
  • Infectious Diseases of Mice and Rats National Research Council 1991.