Mouse Thymic Virus (MTV, MTLV)
DNA virus, enveloped; Family: Herpesviridae.
Affects mice, common in wild mice but rare in laboratory animals.
Serology and/or PCR. Histology (intranuclear inclusion bodies) of thymus in young animals.
Infection of neonates <10days will result in immunosuppression and lesion of thymic necrosis and to a lesser degree splenic and lymph node necrosis. In animals >10days, infection is asymptomatic.
Regular serology as deemed necessary by the individual institutions.
Viru sercretion via saliva with persistence in the salivary glands causing chronic, asymptomatic infection. Possibly via milk as well.
MTV can cause chronic immunosuppression in animals ingfected prior to 10 days of age. In some strains, MTV may cause autoimmune disease.
Pathogen exclusion by exclusion of wild mice and quarantine and screening of new mice.
Infectious Diseases of Mice and Rats National Research Council 1991.
Pathology of Laboratory Rodents and Rabbits, 3rd Edn., Dean H Percy & Stephen W Barthold, 2007.
University of Missouri, Research Animal Diagnostic Laboratory website,