Mouse Kidney Parvovirus MKPV
Cerberus Sciences has compiled literature and information pertaining to Mouse Kidney Parvovirus (MKPV.)
MKPV, a novel pathogen, has been reported in Australian and North American animal facilities. The virus infects immunocompetent and immunodeficient mice, causing chronic renal disease (particularly in the latter). It results in inclusion body nephropathy (IBN), which has been a puzzle for many years, and for which the causative agent has finally been elucidated by a research team at the Centenary Institute, Faculty of Medicine and Health, University of Sydney with their publication “An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis” published in Cell 2018, of which our veterinary pathologist Dr Lorna Rasmussen is one of the authors.
Roediger, B.; Lee, Q.; Tikoo, S.; Cobbin, J. C.; Henderson, J. M.; Jormakka, M.; O'Rourke, M. B.; Padula, M. P.; Pinello, N.; Henry, M.; Wynne, M.; Santagostino, S. F.; Brayton, C. F.; Rasmussen, L.; Lisowski, L.; Tay, S. S.; Harris, D. C.; Bertram, J. F.; Dowling, J. P.; Bertolino, P.; Lai, J. H.; Wu, W.; Bachovchin, W. W.; Wong, J. J.-L.; Gorrell, M. D.; Shaban, B.; Holmes, E. C.; Jolly, C. J.; Monette, S.; Weninger,W.
McInnes E1, Bennett M, O'Hara M, Rasmussen L, Fung P, Nicholls P, Slaven M7, Stevenson R.
Vet Sci. 2015 Jun 11;2(2):84-96. doi: 10.3390/vetsci2020084.